A USB host for wakeup from a sleep state includes a hold memory, a USB host controller, and a USB driver. When going to sleep, the USB driver sends a suspend command to the USB host controller in response to receiving a sleep command. The USB driver also reads a controller context from the USB host controller and saves the controller context in the hold memory. Thereafter, the USB driver turns off one or more supply potentials and one or more clocks in the host controller, and returns a sleep acknowledgement. While in sleep, the interface pins are placed in a hold state and notification to the operating system are disabled.