发明授权
- 专利标题： Manufacture of variable density dosage forms utilizing radiofrequency energy
- 专利标题（中）： 使用射频能量制造可变密度剂型
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申请号： US13052219申请日： 2011-03-21
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公开(公告)号： US08858210B2公开(公告)日： 2014-10-14
- 发明人: Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
- 申请人： Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
- 申请人地址： US NJ Skillman
- 专利权人： McNeil-PPC, Inc.
- 当前专利权人： McNeil-PPC, Inc.
- 当前专利权人地址： US NJ Skillman
- 代理商 William E. McGowan
- 主分类号： B30B11/10
- IPC分类号： B30B11/10 ; A61K9/14 ; A61K9/20 ; A61K9/00 ; A61K31/167 ; A61K31/138 ; B30B11/08 ; A61K31/4545 ; B30B11/02 ; B30B15/34 ; B29C43/00 ; B29C43/36
摘要：
The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.
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