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49 条记录 (耗时 0.019 秒)

    Multi-compartment pre-filled mixing syringes with bypass
    1.
    发明授权
    Multi-compartment pre-filled mixing syringes with bypass 有权

    公开(公告)号：US09731076B2

    公开(公告)日：2017-08-15

    申请号：US13537202

    申请日：2012-06-29

    申请人： Yi-Lan Wang ,  Leo B. Kriksunov

    发明人： Yi-Lan Wang ,  Leo B. Kriksunov

    IPC分类号： A61M5/28 ,  A61M5/315 ,  A61M5/31

    CPC分类号： A61M5/284 ,  A61M5/3129 ,  A61M5/31511

    摘要： The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

    Amplified bioassay
    4.
    发明授权
    Amplified bioassay 失效
    扩增生物测定

    公开(公告)号：US08029985B2

    公开(公告)日：2011-10-04

    申请号：US11162142

    申请日：2005-08-30

    申请人： Leo B Kriksunov ,  Geoffrey Wheelock ,  Lee A Henderson

    发明人： Leo B Kriksunov ,  Geoffrey Wheelock ,  Lee A Henderson

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12P19/34 ,  C12N15/88 ,  A61K51/00

    CPC分类号： B82Y10/00 ,  B82Y5/00 ,  C12Q1/682 ,  C12Q2565/501 ,  C12Q2563/131 ,  C12Q2537/125

    摘要： A method for assaying a biological sample includes forming sensitized microcapsules filled with unique oligomarkers, capturing sensitized microcapsules in the presence of analytes, releasing oligomarkers from microcapsules and detecting and measuring oligomarkers to detect and quantify presence of analyte in biological sample. Using encapsulated oligomarkers provides for an amplified high sensitivity assay and using plurality of oligomarker types provides for a multiplexed assay.

    摘要翻译： 用于测定生物样品的方法包括形成用独特的寡标记物填充的敏化微胶囊，在分析物存在下捕获敏化的微胶囊，从微胶囊中释放寡标记物，并检测和测量寡标记物以检测和定量生物样品中分析物的存在。 使用封装的寡标记物提供扩增的高灵敏度测定并使用多种寡标记类型提供多重测定。

    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION
    5.
    发明申请
    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION 有权
    具有立即释放区域和持续发布区域的片剂的制造

    公开(公告)号：US20110070304A1

    公开(公告)日：2011-03-24

    申请号：US12887560

    申请日：2010-09-22

    申请人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    发明人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    IPC分类号： A61K9/22 ,  A61P29/00 ,  B29C35/02 ,  B29C43/02 ,  B29C35/08

    CPC分类号： A61K9/209 ,  A61J3/10 ,  A61J2200/42 ,  A61K9/2013 ,  A61K9/2095 ,  B29C43/36 ,  B29C2043/3618

    摘要： In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material; and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet; and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.

    摘要翻译： 在一个方面，本发明的特征在于制备包含药物活性剂的片剂的方法，其中所述片剂具有即释释区域和修饰释放区域。 该方法包括以下步骤：（a）形成包含含有药物活性剂和热敏材料的粉末混合物的片剂形式; 和（b）将不同量的能量施加到片剂形状的不同区域以形成片剂，使得：（i）片剂形状的第一区域暴露于所述能量足够的时间以熔化 在第一区域内的热敏材料形成所述片剂的所述改性释放区域; 和（ii）所述片剂形状的第二区域不会暴露于能量，使得所述第二区域形成所述片剂的立即释放区域。

    Photochemically Amplified Bioassay
    6.
    发明申请
    Photochemically Amplified Bioassay 审中-公开
    光化学扩增生物测定

    公开(公告)号：US20090053694A1

    公开(公告)日：2009-02-26

    申请号：US11306378

    申请日：2005-12-26

    申请人： Leo B. Kriksunov

    发明人： Leo B. Kriksunov

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/555

    CPC分类号： G01N33/54373 ,  B01J35/004

    摘要： In the present invention, a reagent capable of immunospecific reaction with the analyte of interest is conjugated to a photocatalytic microparticle. After the immunospecific binding has occurred, the assay amplification is performed by exposing photocatalytic particles to actinic UV light in presence of an oxidizable compound. Photocatalytic particles are catalyzing multiple occurrences of oxidation of oxidizable compound under UV light irradiation resulting in detectable changes such as color change. This provides for amplification of each single act of immunospecific binding and is followed by colormetric detection. Thus a high sensitivity quantitative or qualitative immunoassay can be realized.

    摘要翻译： 在本发明中，与感兴趣的分析物能够进行免疫特异性反应的试剂与光催化微粒共轭。 在发生免疫特异性结合之后，通过在可氧化化合物的存在下将光催化剂颗粒暴露于光化UV光下进行测定扩增。 光催化颗粒在紫外光照射下催化可氧化化合物的多次氧化，导致可检测的变化，例如颜色变化。 这提供了每个单独的免疫特异性结合作用的扩增，然后进行比色检测。 因此，可以实现高灵敏度定量或定性免疫测定。

    Method and device for treating automotive exhaust
    7.
    发明授权
    Method and device for treating automotive exhaust 失效
    汽车尾气处理方法及装置

    公开(公告)号：US07267807B2

    公开(公告)日：2007-09-11

    申请号：US10906175

    申请日：2005-02-06

    申请人： Leo B Kriksunov ,  Constantinos G Vayenas

    发明人： Leo B Kriksunov ,  Constantinos G Vayenas

    IPC分类号： B01D53/94

    CPC分类号： B01D53/32 ,  B01D53/9454 ,  F01N3/0892 ,  F01N3/2026 ,  F01N3/281 ,  Y02T10/22 ,  Y02T10/26

    摘要： The present invention applies the fundamental electrochemical NEMCA effect (Non-Faradaic Electrochemical Modification of Catalytic Activity), to the treatment of the automotive exhaust. A solid electrolyte layer is sandwiched between a conductive catalyst layer and the underlying metal honeycomb multichannel supporting structure forming the exhaust treatment device. Electric current is applied between the catalyst layer and the metallic structure resulting in an increase of catalytic activity of the catalyst. The exhaust stream is passing through the multichannel honeycomb structure and is catalytically treated with increased efficiency.

    摘要翻译： 本发明将基础电化学NEMCA效应（非法拉第电催化活性的电化学改性）应用于汽车尾气的处理。 固体电解质层被夹在导电催化剂层和形成排气处理装置的下面的金属蜂窝多通道支撑结构之间。 在催化剂层和金属结构之间施加电流，导致催化剂的催化活性增加。 废气流通过多通道蜂窝结构，并以更高的效率进行催化处理。