发明授权
- 专利标题： pH-sensitive nanoparticles for oral insulin delivery
- 专利标题（中）： 用于口服胰岛素递送的pH敏感纳米颗粒
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申请号： US13561106申请日： 2012-07-30
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公开(公告)号： US08859004B2公开(公告)日： 2014-10-14
- 发明人: Lijuan Zhang , Li Ling , Li Ying Zhou , Zhi Min Wu , Xin Dong Guo , Wei Jiang , Qian Luo , Yu Qian
- 申请人： Lijuan Zhang , Li Ling , Li Ying Zhou , Zhi Min Wu , Xin Dong Guo , Wei Jiang , Qian Luo , Yu Qian
- 申请人地址： HK The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon
- 专利权人： Nano and Advanced Materials Institute Limited
- 当前专利权人： Nano and Advanced Materials Institute Limited
- 当前专利权人地址： HK The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon
- 代理机构： Ella Cheong Hong Kong
- 代理商 Sam T. Yip
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K38/28
摘要：
The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.
公开/授权文献
- US20130034589A1 pH-SENSITIVE NANOPARTICLES FOR ORAL INSULIN DELIVERY 公开/授权日：2013-02-07