Invention Grant
US08859567B2 Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-D]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
有权
1 - {（2S）-2-氨基-4- [2,4-双（三氟甲基）-5,8-二氢吡啶并[3,4-D]嘧啶-7（6H） - 基] -4 - 氧代丁基} -5,5-二氟 - 哌啶-2-酮酒石酸盐
![Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-D]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate](/docs/US/2014-10-14/US08859567B2/abs.jpg.600x600.jpg)
- Patent Title: Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-D]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate
- Patent Title (中): 1 - {（2S）-2-氨基-4- [2,4-双（三氟甲基）-5,8-二氢吡啶并[3,4-D]嘧啶-7（6H） - 基] -4 - 氧代丁基} -5,5-二氟 - 哌啶-2-酮酒石酸盐
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Application No.: US13879571Application Date: 2011-10-31
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Publication No.: US08859567B2Publication Date: 2014-10-14
- Inventor: Ki Sook Park , Jung Min Yun , Bong Chan Kim , Kyu Young Kim , Ji Hye Lee
- Applicant: Ki Sook Park , Jung Min Yun , Bong Chan Kim , Kyu Young Kim , Ji Hye Lee
- Applicant Address: KR Seoul
- Assignee: LG Life Sciences Ltd.
- Current Assignee: LG Life Sciences Ltd.
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR10-2010-0107868 20101101
- International Application: PCT/KR2011/008186 WO 20111031
- International Announcement: WO2012/060590 WO 20120510
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/519
![Hydrate of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di-hydropyrido[3,4-D]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate](/abs-image/US/2014/10/14/US08859567B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to 1.5 hydrate of of 1-{(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoropiperidin-2-one tartrate, a process for preparing the same, and a pharmaceutical composition for inhibiting DPP-IV, which comprises said compound as the active component.
Public/Granted literature
- US20130203787A1 HYDRATE OF 1--5,5-DIFLUORO-PIPERIDIN-2-ONE TARTRATE Public/Granted day:2013-08-08
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