发明授权
US08859580B2 Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
有权
苯并吡喃和相关支架的芳基和杂芳基羰基衍生物，含有这些化合物的药物及其应用
- 专利标题： Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
- 专利标题（中）： 苯并吡喃和相关支架的芳基和杂芳基羰基衍生物，含有这些化合物的药物及其应用
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申请号： US12742680申请日： 2008-11-14
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公开(公告)号： US08859580B2公开(公告)日： 2014-10-14
- 发明人: Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
- 申请人： Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; David L. Kershner
- 优先权： EP07120914 20071116; EP07123942 20071221; EP08155137 20080424
- 国际申请： PCT/EP2008/065577 WO 20081114
- 国际公布： WO2009/063061 WO 20090522
- 主分类号： C07D221/26
- IPC分类号： C07D221/26 ; C07D417/06 ; C07D401/06 ; C07D471/08 ; C07D498/08 ; C07D413/14 ; C07D413/06 ; C07D405/06 ; C07D401/14 ; C07D451/06 ; C07D403/06
摘要：
The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
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