发明授权
- 专利标题： Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use
- 专利标题（中）： 对双链DNA具有高选择性的荧光化合物及其使用方法
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申请号： US13861123申请日： 2013-04-11
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公开(公告)号： US08865904B2公开(公告)日： 2014-10-21
- 发明人: Jolene Bradford , Ching-Ying Cheung , Shih-Jung Huang , Patrick Pinson , Stephen Yue
- 申请人： Life Technologies Corporation
- 申请人地址： US CA Carlsbad
- 专利权人： Life Technologies Corporation
- 当前专利权人： Life Technologies Corporation
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Life Technologies Corporation
- 主分类号： C07D215/00
- IPC分类号： C07D215/00 ; C07D417/04 ; C07D215/10 ; C07D277/72 ; C07D277/74 ; G01N21/64 ; C07D417/14 ; C07D417/06 ; C07D215/227
摘要：
Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
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