发明授权
- 专利标题： pH-responsive liposome
- 专利标题（中）： pH响应脂质体
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申请号： US13255231申请日： 2010-03-10
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公开(公告)号： US08871252B2公开(公告)日： 2014-10-28
- 发明人: Shinji Takeoka , Yousuke Obata , Satoru Nakagawa , Shinya Ohtsubo , Yuji Kawasaki
- 申请人： Shinji Takeoka , Yousuke Obata , Satoru Nakagawa , Shinya Ohtsubo , Yuji Kawasaki
- 申请人地址： JP Tokyo
- 专利权人： Nanotheta Co, Ltd.
- 当前专利权人： Nanotheta Co, Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2009-058063 20090311
- 国际申请： PCT/JP2010/054042 WO 20100310
- 国际公布： WO2010/104128 WO 20100916
- 主分类号： A61K9/127
- IPC分类号： A61K9/127
摘要：
The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment.The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.
公开/授权文献
- US20120064148A1 PH-RESPONSIVE LIPOSOME 公开/授权日：2012-03-15
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