Invention Grant
US08871463B2 Method for screening a glutamate release inhibitor in an astrocyte
有权
在星形胶质细胞中筛选谷氨酸释放抑制剂的方法
- Patent Title: Method for screening a glutamate release inhibitor in an astrocyte
- Patent Title (中): 在星形胶质细胞中筛选谷氨酸释放抑制剂的方法
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Application No.: US13948476Application Date: 2013-07-23
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Publication No.: US08871463B2Publication Date: 2014-10-28
- Inventor: Changjoon Justin Lee , Soo Jin Oh , Eun Mi Hwang , Dong Ho Woo
- Applicant: Korea Institute of Science and Technology
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: Staas & Halsey LLP
- Priority: KR10-2012-0109460 20120928
- Main IPC: C12Q1/02
- IPC: C12Q1/02
Abstract:
The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.
Public/Granted literature
- US20140093490A1 GLUTAMATE RELEASE FROM ASTROCYTE Public/Granted day:2014-04-03
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