公开(公告)号：US11021586B2

公开(公告)日：2021-06-01

申请号：US15438215

申请日：2017-02-21

Applicant: Korea Institute of Science and Technology

Inventor： Nakwon Choi ,  Sohyun Kim ,  Sohyeon Jeong ,  Eui Sung Yoon ,  Changjoon Justin Lee ,  Il-Joo Cho

IPC: B29C43/18 ,  C08J7/043 ,  C08J7/04 ,  C12M3/00 ,  C12M1/12 ,  C12N5/00 ,  C12N5/09

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.

公开(公告)号：US08871463B2

公开(公告)日：2014-10-28

申请号：US13948476

申请日：2013-07-23

Applicant: Korea Institute of Science and Technology

Inventor： Changjoon Justin Lee ,  Soo Jin Oh ,  Eun Mi Hwang ,  Dong Ho Woo

IPC: C12Q1/02

CPC classification number: A61K38/45 ,  A61K31/135 ,  A61K31/137 ,  A61K31/185 ,  A61K31/225 ,  A61K31/4045 ,  A61K31/4168 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/49 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5375 ,  A61K31/662 ,  A61K35/74 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  C07K7/06 ,  C07K7/08 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/5008 ,  G01N33/5058 ,  G01N33/6872

Abstract: The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.

Abstract translation: 本发明研究谷氨酸释放和谷氨酸释放的两种模式，从而通过控制天冬氨酸的谷氨酸释放，为神经元保护和神经传递加速提供了有用的技术。 因此，本发明提供了星形细胞性谷氨酸的快速释放和/或慢速释放抑制剂，抑制剂的筛选方法以及改善，预防和/或治疗与 通过Ca2 +活化的阴离子通道过度释放谷氨酸，抑制快速谷氨酸释放。

公开(公告)号：US09834537B2

公开(公告)日：2017-12-05

申请号：US14092151

申请日：2013-11-27

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Roh ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Seok Jin Hwang ,  Jong Hoon Jung

IPC: C07C229/56 ,  C07D333/10 ,  C07D333/40 ,  C07C229/58

CPC classification number: C07D333/40 ,  C07C229/56 ,  C07C229/58

Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.

公开(公告)号：US09803167B2

公开(公告)日：2017-10-31

申请号：US14950710

申请日：2015-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Nakwon Choi ,  Eun-Mi Hur ,  Sohyun Kim ,  Sun-Kyoung Im ,  Eui Sung Yoon ,  Changjoon Justin Lee

IPC: B29C55/00 ,  C12M1/42 ,  B29C55/02 ,  B29C55/20 ,  B29C55/12 ,  C08J5/00 ,  A61L27/16 ,  A61L27/38 ,  A61L27/50

CPC classification number: C12M35/04 ,  A61L27/165 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L2430/32 ,  B29C55/02 ,  B29C55/023 ,  B29C55/12 ,  B29C55/20 ,  C08J5/00

Abstract: The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.

公开(公告)号：US09469653B2

公开(公告)日：2016-10-18

申请号：US14164616

申请日：2014-01-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Changjoon Justin Lee ,  Seonmi Jo ,  Boeun Yoon ,  Hyunah Choo ,  Ji Yoon Kim ,  Daesoo Kim

IPC: C07D513/04 ,  G01N33/68 ,  C07D498/04 ,  G01N33/50 ,  G01N33/94

CPC classification number: C07D498/04 ,  C07D513/04 ,  C12N2503/02 ,  G01N33/5058 ,  G01N33/6896 ,  G01N33/9426 ,  G01N2800/2814 ,  G01N2800/302

Abstract: A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.

Abstract translation: 用于预防或治疗退行性脑病的药物组合物，以及筛选用于预防或治疗退行性脑病的材料的方法。 该方法可以有效地筛选用于预防或治疗退行性脑病的预防性或治疗性候选物质。 可以使用包括用于预防或治疗退行性脑病的筛选材料的药物组合物来有效地预防或治疗各种退行性脑疾病。

公开(公告)号：US09458120B2

公开(公告)日：2016-10-04

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  A61K31/496 ,  C07D295/088 ,  C07D231/40 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D233/64 ,  C12N5/071 ,  C07D401/04 ,  C07D403/06 ,  C07D413/04 ,  A61K31/495 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 其中*表示（R） - 型或（S） - 型，X选自氢，卤素和具有1至4个碳原子的取代或未取代的直链或支链烷基，n表示X 和1〜5的整数，其中在具有1〜4个碳原子的取代的直链或支链烷基中至少有一个氢被卤素取代。 该衍生物可用于阻断T型钙通道和/或TREK通道，以及用于预防和/或治疗T型钙通道和/或TREK通道相关疾病。

公开(公告)号：US20150166496A1

公开(公告)日：2015-06-18

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  C07D233/64 ,  C12N5/071 ,  C07D211/58 ,  C07D211/52 ,  C07D295/088 ,  C07D211/22

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 本发明涉及新的苯氧基丙醇衍生物，其用于阻断T型钙通道和/或TREK通道的用途及其用于预防和/或治疗T型钙通道和/或TREK通道相关疾病的用途。