发明授权
US08877801B2 Compounds and compositions as selective estrogen receptor degraders
有权
化合物和组合物作为选择性雌激素受体降解物
- 专利标题： Compounds and compositions as selective estrogen receptor degraders
- 专利标题（中）： 化合物和组合物作为选择性雌激素受体降解物
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申请号： US14178652申请日： 2014-02-12
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公开(公告)号： US08877801B2公开(公告)日： 2014-11-04
- 发明人: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- 申请人： Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Scott W. Reid
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D333/64 ; A61K45/06 ; A61K31/506 ; C07D413/12 ; A61K31/422 ; C07D413/04 ; C07D333/66 ; A61K31/4245 ; A61K31/4196 ; C07D409/12 ; A61K31/4436
摘要：
The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
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