Invention Grant
US08877801B2 Compounds and compositions as selective estrogen receptor degraders
有权
化合物和组合物作为选择性雌激素受体降解物
- Patent Title: Compounds and compositions as selective estrogen receptor degraders
- Patent Title (中): 化合物和组合物作为选择性雌激素受体降解物
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Application No.: US14178652Application Date: 2014-02-12
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Publication No.: US08877801B2Publication Date: 2014-11-04
- Inventor: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- Applicant: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Main IPC: A61K31/381
- IPC: A61K31/381 ; C07D333/64 ; A61K45/06 ; A61K31/506 ; C07D413/12 ; A61K31/422 ; C07D413/04 ; C07D333/66 ; A61K31/4245 ; A61K31/4196 ; C07D409/12 ; A61K31/4436
Abstract:
The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
Public/Granted literature
- US20140235660A1 COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS Public/Granted day:2014-08-21
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