发明授权
- 专利标题： Amphiphiles for protein solubilization and stabilization
- 专利标题（中）： 用于蛋白质溶解和稳定的两亲物
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申请号： US13608385申请日： 2012-09-10
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公开(公告)号： US08877906B2公开(公告)日： 2014-11-04
- 发明人: Samuel Helmer Gellman , Pil Seok Chae , Phillip D. Laible , Marc J. Wander
- 申请人： Samuel Helmer Gellman , Pil Seok Chae , Phillip D. Laible , Marc J. Wander
- 申请人地址： US WI Madison US IL Chicago
- 专利权人： Wisconsin Aumni Research Foundation,UChicago Argonne, LLC
- 当前专利权人： Wisconsin Aumni Research Foundation,UChicago Argonne, LLC
- 当前专利权人地址： US WI Madison US IL Chicago
- 代理机构： DeWitt Ross & Stevens S.C.
- 代理商 Joseph T. Leone, Esq.
- 主分类号： C07H15/00
- IPC分类号： C07H15/00 ; C07H15/02 ; C07H15/18 ; A61K31/7028
摘要：
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
公开/授权文献
- US20130001465A1 AMPHIPHILES FOR PROTEIN SOLUBILIZATION AND STABILIZATION 公开/授权日：2013-01-03
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