发明授权
- 专利标题: Transdermal therapeutic system having stabilized membrane
- 专利标题(中): 透皮治疗系统具有稳定的膜
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申请号: US12921988申请日: 2009-02-28
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公开(公告)号: US08882729B2公开(公告)日: 2014-11-11
- 发明人: Michael Horstmann , Patrick Mohr , Mohammad Sameti
- 申请人: Michael Horstmann , Patrick Mohr , Mohammad Sameti
- 申请人地址: DE Andernach
- 专利权人: LTS Lohmann Therapie Systeme AG
- 当前专利权人: LTS Lohmann Therapie Systeme AG
- 当前专利权人地址: DE Andernach
- 代理机构: Frommer Lawrence & Haug LLP
- 优先权: DE102008013701 20080311
- 国际申请: PCT/EP2009/001446 WO 20090228
- 国际公布: WO2009/112167 WO 20090917
- 主分类号: A61M35/00
- IPC分类号: A61M35/00 ; A61K9/00 ; A61K9/70
摘要:
The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.