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    Transdermal therapeutic system reinforced by ultrasounds
    3.
    发明授权
    Transdermal therapeutic system reinforced by ultrasounds 有权
    透皮治疗系统由超声波加强

    公开(公告)号：US09114240B2

    公开(公告)日：2015-08-25

    申请号：US12303470

    申请日：2007-05-11

    Applicant: Michael Horstmann ,  Andreas Koch

    Inventor： Michael Horstmann ,  Andreas Koch

    IPC: A61M37/00 ,  A61N7/00 ,  A61K9/00

    CPC classification number: A61M37/0092 ,  A61M2037/0007 ,  A61N7/00

    Abstract: The invention relates to a transdermal therapeutic system (10) comprising a pharmaceutical active agent formulation (13), an adhesive layer (11) comprising a contact surface (12), and at least one ultrasound transmitter (21), the side of the ultrasound transmitter opposing the contact surface being directly or indirectly adjacent to the pharmaceutical active agent formulation. The transdermal therapeutic system is a multi-layered laminate, one of the laminate layers comprising the ultrasound transmitter, another comprising the adhesive layer, and another comprising the pharmaceutical active agent formulation. Furthermore, from a top view, at least in a plane position of the transdermal therapeutic system, all of the laminate layers (11, 21, 14) are at least approximately mutually congruent and are at least approximately the size of the contact surface. The inventive system provides an ultrasound-reinforced transdermal therapeutic system characterized by an extensive use of active agents, enabling an improved absorption of active agents through the skin.

    Abstract translation: 本发明涉及包含药物活性剂制剂（13），包含接触表面（12）的粘合剂层（11）和至少一个超声波发射器（21）的透皮治疗系统（10），超声波的一侧 反向接触表面的发射体直接或间接地邻近药物活性剂制剂。 透皮治疗系统是多层层压体，层压层中的一个包括超声波发射器，另一个包括粘合剂层，另一个包含药物活性剂制剂。 此外，从顶视图至少在透皮治疗系统的平面位置，所有的层压层（11,21,14）至少大致相等，并且至少大约为接触表面的尺寸。 本发明的系统提供超声增强的透皮治疗系统，其特征在于广泛使用活性剂，能够改善活性剂通过皮肤的吸收。

    TRANSDERMAL THERAPEUTIC SYSTEM HAVING UREA COMPONENTS
    5.
    发明申请
    TRANSDERMAL THERAPEUTIC SYSTEM HAVING UREA COMPONENTS 有权
    具有尿素成分的超声治疗系统

    公开(公告)号：US20100310634A1

    公开(公告)日：2010-12-09

    申请号：US12865465

    申请日：2008-12-09

    Applicant: Michael Horstmann ,  Gerd Hoffmann ,  Sandra Wiedersberg

    Inventor： Michael Horstmann ,  Gerd Hoffmann ,  Sandra Wiedersberg

    IPC: A61K9/70 ,  A61P21/02 ,  A61P9/12 ,  A61P25/26 ,  A61P1/08

    CPC classification number: A61K9/7061

    Abstract: The invention relates to a transdermal therapeutic system (TTS) for administering pharmaceutical agents through the skin, comprising a back layer (R) impermeable to the agent and at least one layer (S) comprising the agent, wherein the layer (H) facing the skin comprises urea in solid form, allowing continuous administration of large quantities of agent over a long period of time.

    Abstract translation: 本发明涉及一种用于通过皮肤施用药剂的透皮治疗系统（TTS），其包括不可渗透到所述药剂的背层（R）和包含所述药剂的至少一层（S），其中所述层（H） 皮肤包含固体形式的尿素，允许长时间连续施用大量的药剂。

    Transdermal therapeutic system with a highly effective neuroleptic agent
    6.
    发明授权
    Transdermal therapeutic system with a highly effective neuroleptic agent 有权
    透皮治疗系统具有高效神经安定药

    公开(公告)号：US07560121B1

    公开(公告)日：2009-07-14

    申请号：US09959201

    申请日：2000-04-07

    Applicant: Stefan Bracht ,  Michael Horstmann

    Inventor： Stefan Bracht ,  Michael Horstmann

    IPC: A61L15/16 ,  A61M37/00

    CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K31/496 ,  A61K31/5415

    Abstract: A transdermal therapeutic system consisting of a backing layer, at least one active substance-containing matrix layer, which may at the same time possess pressure-sensitive adhesive properties, as well as a removable protective layer is characterized by a content of a neuroleptic, a content of at least one permeation enhancer as well as by a layer which is pressure-sensitive adhesive on the skin-facing side and based on polymers which are pure hydrocarbons.

    Abstract translation: 由背衬层，至少一种含有活性物质的基质层（可以同时具有压敏粘合剂性质）以及可除去的保护层组成的透皮治疗系统的特征在于精神抑制剂， 至少一种渗透增强剂的含量以及在面向皮肤的一侧上的压敏粘合剂层，并且基于作为纯烃的聚合物。

    Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance
    7.
    发明授权
    Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance 有权
    单独配制的箔形式，其与液体接触迅速分解，并含有活性物质，特别是芳族物质

    公开(公告)号：US06682756B1

    公开(公告)日：2004-01-27

    申请号：US09319909

    申请日：1999-07-15

    Applicant: Michael Horstmann ,  Wolfgang Laux

    Inventor： Michael Horstmann ,  Wolfgang Laux

    IPC: A61K970

    CPC classification number: A61K9/0056 ,  A61K9/2072 ,  A61K9/70 ,  A61K9/7007

    Abstract: Individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w) of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.

    Abstract translation: 单独计量的含活性物质，特别是含芳族化合物的膜状给药形式，在与液体接触时迅速崩解，其中芳族化合物作为分散在外部的液滴形式的内部脂溶性相存在 固体但水溶性相的特征在于，所述外相含有：至少40％（w / w）的聚乙烯醇，0-30％（w / w）的表面活性物质， 相对于外相的内相在每个情况下相对于无水部分为0.1-30％（w / w）。

    Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile
    8.
    发明授权
    Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile 有权
    通过形成多层桩将多个单独的片状给药形式插入分配器中的方法和装置

    公开(公告)号：US06659442B1

    公开(公告)日：2003-12-09

    申请号：US09622562

    申请日：2000-09-20

    Applicant: Peter Steinborn ,  Horst Dzekan ,  Klaus Schumann ,  Wolfgang Laux ,  Michael Horstmann

    Inventor： Peter Steinborn ,  Horst Dzekan ,  Klaus Schumann ,  Wolfgang Laux ,  Michael Horstmann

    IPC: B65H3916

    CPC classification number: B65H35/06 ,  A61K9/006 ,  B65H39/16 ,  B65H2701/1752 ,  B65H2701/176 ,  Y10T83/2042 ,  Y10T83/2046 ,  Y10T83/222

    Abstract: A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

    Abstract translation: 一种将多个分离的片状给药形式引入到分配器中的方法，该分配器形成多层堆叠以进行单独的剂量去除，卷材卷绕在辊上作为起始材料，利用以下步骤。 在第一步骤中，从多个辊同时拉出数个对应于堆叠的所述带的多个片状层。 在另一步骤中，使用引导装置将各个带组合在一起形成多层股线，该多股股票在另一个步骤中被向前拉到切割站，其中一次堆叠被一次切断，并且其中长度段 对应于堆叠的多层股线在通过切割装置从剩余的多层股线切断之前基本上在分配器中。

    Transdermal therapeutic system identified without printing inks
    9.
    发明授权
    Transdermal therapeutic system identified without printing inks 失效
    未经印刷油墨鉴定的透皮治疗系统

    公开(公告)号：US6080421A

    公开(公告)日：2000-06-27

    申请号：US981133

    申请日：1998-04-15

    Applicant: Peter Steinborn ,  Michael Horstmann

    Inventor： Peter Steinborn ,  Michael Horstmann

    IPC: A61F13/02 ,  A61K9/70 ,  A61L15/58 ,  A61F13/00 ,  A61L15/03

    CPC classification number: A61K9/7023

    Abstract: The invention refers to a transdermal therapeutic system for the delivery of active agents to the human body.The backing layer consists of common pharmaceutical plastic layer laminates which require labeling, e.g. by printing. The problem to solve lies in toxicological, technological and drug law disadvantages of pigment- or varnish-printing.According to the invention, the coding does not consist of an ink- or pigment layer but in an effect on surface properties of the backing layer corresponding to the coding.

    Abstract translation: PCT No.PCT / DE96 / 00699 Sec。 371日期：1998年5月15日 102（e）日期1998年5月15日PCT提交1996年4月23日PCT公布。 出版物WO96 / 38187 日期1996年12月5日本发明涉及用于将活性剂递送至人体的透皮治疗系统。 背衬层由需要标记的普通药用塑料层层压板组成。 通过打印。 解决的问题在于颜料或清漆印刷的毒理学，技术和药物法缺点。 根据本发明，编码不包括油墨或颜料层，而是对与编码相对应的背衬层的表面性质的影响。

    Volatile active substance containing plaster that may be produced without solvents
    10.
    发明授权
    Volatile active substance containing plaster that may be produced without solvents 失效
    挥发性活性物质含有石膏，可在无溶剂的情况下生产

    公开(公告)号：US5902601A

    公开(公告)日：1999-05-11

    申请号：US959541

    申请日：1997-10-24

    Applicant: Michael Horstmann

    Inventor： Michael Horstmann

    IPC: A61K9/70 ,  A61K31/616 ,  A61F13/00

    CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K9/7092

    Abstract: An active substance-containing adhesive patch with a pressure sensitive fixing device, containing at least one readily volatile ingredient, consisting of a substantially active substance-impermeable backing layer, at least two active substance-containing matrix layers and a removable protective layer, whereby the matrix layer containing the readily volatile active substance is laminated on a separately produced composite of one or more further matrix layers which are active substance-free, is characterized in that the first active substance-containing matrix layer consists of a spreadable molecularly disperse solution of the matrix base material in the readily volatile ingredient as the exclusive solvent, the composite which is obtained after laminating forming an active substance matrix that is as a whole shear-resistant after migration of the readily volatile ingredient into the composite.

    Abstract translation: 一种含有活性物质的粘合贴剂，其具有压敏定影装置，其含有至少一种容易挥发的成分，其由基本上活性物质不可渗透的背衬层，至少两种含活性物质的基质层和可除去的保护层组成， 将含有易挥发性活性物质的基质层层压在单独制造的一种或多种无活性物质的另外的基质层的复合物上，其特征在于，第一含活性物质的基质层由可扩散的分子分散溶液 作为专用溶剂的容易挥发成分中的基质基材，在层压后形成活性物质基质后获得的复合物，该活性物质基质在容易挥发成分迁移到复合材料中后整体抗剪切。

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