发明授权
US08883721B2 Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
有权
抑制生长素释放肽/生长激素分泌受体途径及其用途的方法
- 专利标题： Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
- 专利标题（中）： 抑制生长素释放肽/生长激素分泌受体途径及其用途的方法
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申请号： US13320408申请日： 2010-05-12
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公开(公告)号： US08883721B2公开(公告)日： 2014-11-11
- 发明人: Cyril Y. Bowers , David H. Coy , Simon J. Hocart , Gloria S. Tannenbaum
- 申请人： Cyril Y. Bowers , David H. Coy , Simon J. Hocart , Gloria S. Tannenbaum
- 申请人地址： CA Montreal US LA New Orleans
- 专利权人： McGill University,The Administrators of the Tulane Educational Fund
- 当前专利权人： McGill University,The Administrators of the Tulane Educational Fund
- 当前专利权人地址： CA Montreal US LA New Orleans
- 代理机构： Nixon Peabody LLP.
- 国际申请： PCT/US2010/034570 WO 20100512
- 国际公布： WO2010/132580 WO 20101118
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; A61K38/10 ; C07K7/06 ; C07K7/08 ; A61K31/00 ; A61K45/06 ; A61K31/404 ; A61K38/16 ; A61K38/25
摘要：
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A11-A12-A13-Gly-Ser-A14-Phe-Leu-A15-A16-A17-A18 (SEQ ID NO: 93), wherein each of A11, A12, and A13 is independently absent, an amino acid, or an amino protecting group; each of A15, A16, A17, and A18 is independently absent or an amino acid; and A14 is a serine conjugated with a —(O)C1-C20alky or a diaminopropionic acid conjugated with a —C(O)C1-C20alkyl group, provided that at least one of A11, A12, or A13 is present.
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