Invention Grant
US08883751B2 Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity
有权
含有microRNA-21抑制剂的组合物，用于增强辐射敏感性
- Patent Title: Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity
- Patent Title (中): 含有microRNA-21抑制剂的组合物，用于增强辐射敏感性
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Application No.: US12599735Application Date: 2008-07-30
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Publication No.: US08883751B2Publication Date: 2014-11-11
- Inventor: Jong Bae Park , Seung Hoon Lee , Hee Jin Kwak , Tae Hoon Kim , Heon Yoo , Donghee Lee , Eun Kyoung Park , Hea Jin Kim
- Applicant: Jong Bae Park , Seung Hoon Lee , Hee Jin Kwak , Tae Hoon Kim , Heon Yoo , Donghee Lee , Eun Kyoung Park , Hea Jin Kim
- Applicant Address: KR Goyang-si
- Assignee: National Cancer Center
- Current Assignee: National Cancer Center
- Current Assignee Address: KR Goyang-si
- Agency: Seed IP Law Group PLLC
- Priority: KR10-2008-0071891 20080723
- International Application: PCT/KR2008/004431 WO 20080730
- International Announcement: WO2010/010980 WO 20100128
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.
Public/Granted literature
- US20110021601A1 COMPOSITION CONTAINING MICRORNA-21 INHIBITOR FOR ENHANCING RADIATION SENSITIVITY Public/Granted day:2011-01-27
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