公开(公告)号：US08883751B2

公开(公告)日：2014-11-11

申请号：US12599735

申请日：2008-07-30

Applicant: Jong Bae Park ,  Seung Hoon Lee ,  Hee Jin Kwak ,  Tae Hoon Kim ,  Heon Yoo ,  Donghee Lee ,  Eun Kyoung Park ,  Hea Jin Kim

Inventor： Jong Bae Park ,  Seung Hoon Lee ,  Hee Jin Kwak ,  Tae Hoon Kim ,  Heon Yoo ,  Donghee Lee ,  Eun Kyoung Park ,  Hea Jin Kim

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC classification number: A61K41/0038 ,  A61K31/00 ,  A61K31/7105 ,  C12N15/113 ,  C12N2310/113

Abstract: Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.

Abstract translation: 公开了一种其中微小RNA-21抑制剂作为活性成分的辐射敏感性增强组合物。 microRNA-21抑制剂是与microRNA-21互补结合的反义核酸分子。 组合物可以与照射一起施用于患者。 抑制剂可以作为放射增敏剂，增强这种辐射对microRNA-21表达水平，特别是胶质瘤的癌症的治疗效果。

公开(公告)号：US20110124712A1

公开(公告)日：2011-05-26

申请号：US12599733

申请日：2008-07-25

Applicant: Jong Bae Park ,  Seung Hoon Lee ,  Eun Kyoung Park ,  Donghee Lee ,  Hee-Seok Yang ,  Heon Yoo ,  Hea Jin Kim ,  Tae Hoon Kim ,  Hee Jin Kwak

Inventor： Jong Bae Park ,  Seung Hoon Lee ,  Eun Kyoung Park ,  Donghee Lee ,  Hee-Seok Yang ,  Heon Yoo ,  Hea Jin Kim ,  Tae Hoon Kim ,  Hee Jin Kwak

IPC: A61K31/7105 ,  C07H21/02 ,  C12N15/63 ,  C40B40/06 ,  A61P35/00 ,  A61P9/10 ,  A61P9/00 ,  A61P17/00 ,  A61P27/06 ,  A61P27/02 ,  A61P19/02 ,  A61P17/06 ,  A61P25/28

CPC classification number: A61K31/7105

Abstract: Disclosed is an anticancer composition for the treatment of hypoxia-induced angiogenesis-associated diseases including cancers. It comprises a microRNA-125 nucleic acid molecule. Also, methods of inhibiting angiogenesis, suppressing the invasion and metastasis of cancer cells, and treating cancers are provided.

Abstract translation: 公开了用于治疗缺氧诱导的血管生成相关疾病（包括癌症）的抗癌组合物。 它包含微小RNA-125核酸分子。 此外，还提供了抑制血管生成，抑制癌细胞的侵袭和转移以及治疗癌症的方法。

公开(公告)号：US20110021601A1

公开(公告)日：2011-01-27

申请号：US12599735

申请日：2008-07-30

Applicant: Jong Bae Park ,  Seung Hoon Lee ,  Hee Jin Kwak ,  Tae Hoon Kim ,  Heon Yoo ,  Donghee Lee ,  Eun Kyoung Park ,  Hea Jin Kim

Inventor： Jong Bae Park ,  Seung Hoon Lee ,  Hee Jin Kwak ,  Tae Hoon Kim ,  Heon Yoo ,  Donghee Lee ,  Eun Kyoung Park ,  Hea Jin Kim

IPC: A61K31/713 ,  C07H21/02 ,  C12N15/63 ,  A61P35/00

CPC classification number: A61K41/0038 ,  A61K31/00 ,  A61K31/7105 ,  C12N15/113 ,  C12N2310/113

Abstract: Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.

Abstract translation: 公开了一种其中微小RNA-21抑制剂作为活性成分的辐射敏感性增强组合物。 microRNA-21抑制剂是与microRNA-21互补结合的反义核酸分子。 组合物可以与照射一起施用于患者。 抑制剂可以作为放射增敏剂，增强这种辐射对microRNA-21表达水平，特别是胶质瘤的癌症的治疗效果。