A switch-driving circuit suitable for driving a full-controlled power switch combination is disclosed. The switch-driving circuit includes a first pulse-width modulator, a high-voltage isolation pulse transformer module and a plurality of output modules. The high-voltage isolation pulse transformer module includes a magnetic core connected to multiple output modules in a one-to-many way, or includes multiple magnetic cores connected to multiple output modules in a one-to-one way. Each output module includes a second pulse-width modulator and a driving-power amplifier. The full-controlled power switch combination includes a plurality of full-controlled power switches. The driving-power amplifier is coupled between the second pulse-width modulator and one of the full-controlled power switches.