In a method of driving a display panel, a voltage of a first polarity with respect to a reference voltage is outputted to an n-th data line and an (n+1)-th data line (‘n’ is a natural number), respectively, and a voltage of a second polarity with respect to the reference voltage is outputted to an (n+2)-th data line and an (n+3)-th data line, respectively, during an N-th frame (‘N’ is a natural number). Then, a voltage of the first polarity is outputted to the n-th data line, a voltage of the second polarity is outputted to the (n+1)-th data line and the (n+2)-th data line, respectively, and a voltage of the first polarity is outputted to the (n+3)-th data line, during an (N+1)-th frame.