Invention Grant
US08894999B2 Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
有权
使用DR6和p75拮抗剂促进神经系统细胞的存活
- Patent Title: Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
- Patent Title (中): 使用DR6和p75拮抗剂促进神经系统细胞的存活
-
Application No.: US13936084Application Date: 2013-07-05
-
Publication No.: US08894999B2Publication Date: 2014-11-25
- Inventor: Sha Mi , Kenneth J. Rhodes , R. Blake Pepinsky
- Applicant: Biogen Idec MA Inc.
- Applicant Address: US MA Cambrigde
- Assignee: Biogen Idec MA Inc.
- Current Assignee: Biogen Idec MA Inc.
- Current Assignee Address: US MA Cambrigde
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; A61K38/00 ; C07K14/00 ; C12N15/113 ; A61K31/713 ; A61K38/17 ; C07K16/28 ; C12N15/11 ; A61K31/7088 ; C07K14/705
Abstract:
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6 and/or p75 antagonists. In addition, the methods described herein include methods of promoting survival of cells of the nervous system using DR6 antagonists, optionally in combination with p75 antagonists, and methods of treating neurodegenerative conditions by the administration of a DR6 antagonists, optionally in combination with a p75 antagonist.
Public/Granted literature
- US20140010826A1 Use of DR6 and p75 Antagonists to Promote Survival of Cells of the Nervous System Public/Granted day:2014-01-09
Information query
