发明授权
- 专利标题： Method for preparing a site-specific physiologically active polypeptide conjugate
- 专利标题（中）： 制备位点特异性生理活性多肽缀合物的方法
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申请号： US13255199申请日： 2010-03-18
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公开(公告)号： US08895281B2公开(公告)日： 2014-11-25
- 发明人: Dae Hae Song , Jae Hee Shin , Jae Min Lee , Young Kyung Park , Se Chang Kwon , Gwan Sun Lee
- 申请人： Dae Hae Song , Jae Hee Shin , Jae Min Lee , Young Kyung Park , Se Chang Kwon , Gwan Sun Lee
- 申请人地址： KR Hwaseong-si
- 专利权人： Hanmi Science Co., Ltd
- 当前专利权人： Hanmi Science Co., Ltd
- 当前专利权人地址： KR Hwaseong-si
- 代理机构： Sughrue Mion, PLLC
- 优先权： KR10-2009-0023953 20090320
- 国际申请： PCT/KR2010/016740 WO 20100318
- 国际公布： WO2010/107256 WO 20100923
- 主分类号： C12N9/00
- IPC分类号： C12N9/00 ; C07K7/04 ; C07K14/00 ; C07K1/107 ; A61K47/48 ; C07K14/575 ; C07K14/605 ; C07K14/62
摘要：
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.
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