Invention Grant
- Patent Title: Quinazoline-2,4-dione derivatives
- Patent Title (中): 喹唑啉-2,4-二酮衍生物
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Application No.: US14238415Application Date: 2012-08-10
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Publication No.: US08916573B2Publication Date: 2014-12-23
- Inventor: Christian Hubschwerlen , Georg Rueedi , Jean-Philippe Surivet , Cornelia Zumbrunn Acklin
- Applicant: Christian Hubschwerlen , Georg Rueedi , Jean-Philippe Surivet , Cornelia Zumbrunn Acklin
- Applicant Address: CH Allschwil
- Assignee: Actelion Pharmaceuticals Ltd.
- Current Assignee: Actelion Pharmaceuticals Ltd.
- Current Assignee Address: CH Allschwil
- Agency: Hunton & Williams LLP
- Priority: WOPCT/IB2011/053583 20110811
- International Application: PCT/IB2012/054080 WO 20120810
- International Announcement: WO2013/021363 WO 20130214
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/517 ; C07D239/72 ; C07D401/00

Abstract:
The invention relates to antibacterial compounds of formula (I), wherein R1 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; R2 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy or pyrrolidin-1-yl; R3 is H, halogen, (C1-C3)alkyl, (C1-C3)alkoxy, vinyl or 2-methoxycarbonyvinyl or R2 and R3 together with the two carbon atoms which bear them form a phenyl ring; R4 is H, halogen, (C1-C3)alkyl or (C1-C3)alkoxy; and R5 is H, (C1-C3)alkyl or cyclopropyl, or R4 and R5form together a —CH2CH2CH2— group; A is the divalent group —CH2—, —CH2CH2—, #—CH(OH)CH2—*, #—CH2N(R6)—* and —CH2NHCH2—, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; R6 is H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.
Public/Granted literature
- US20140171425A1 QUINAZOLINE-2,4-DIONE DERIVATIVES Public/Granted day:2014-06-19
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