发明授权
US08916574B2 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
有权
用作酪氨酸激酶抑制剂的4-(取代的苯胺基) - 喹唑啉衍生物
- 专利标题: 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
- 专利标题(中): 用作酪氨酸激酶抑制剂的4-(取代的苯胺基) - 喹唑啉衍生物
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申请号: US13498547申请日: 2010-09-20
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公开(公告)号: US08916574B2公开(公告)日: 2014-12-23
- 发明人: Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
- 申请人: Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
- 申请人地址: CN Jinan, Shangdong
- 专利权人: Qilu Pharmaceutical Co., Ltd.
- 当前专利权人: Qilu Pharmaceutical Co., Ltd.
- 当前专利权人地址: CN Jinan, Shangdong
- 优先权: CN200910177401 20090928
- 国际申请: PCT/CN2010/001449 WO 20100920
- 国际公布: WO2011/035540 WO 20110331
- 主分类号: A01N43/54
- IPC分类号: A01N43/54 ; A61K31/517 ; C07D239/72 ; C07D401/00
摘要:
The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.