公开(公告)号：US08916574B2

公开(公告)日：2014-12-23

申请号：US13498547

申请日：2010-09-20

申请人： Jingyi Wang ,  Chuanwen Fan ,  Long Zhang ,  Zhongru Guo ,  Ying Li ,  Shaobo Yang ,  Shousheng Yan ,  Jianrong Zhu ,  Qingmin Yang ,  Minghui Zhang

发明人： Jingyi Wang ,  Chuanwen Fan ,  Long Zhang ,  Zhongru Guo ,  Ying Li ,  Shaobo Yang ,  Shousheng Yan ,  Jianrong Zhu ,  Qingmin Yang ,  Minghui Zhang

IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D239/72 ,  C07D401/00

CPC分类号： C07D405/04

摘要： The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

摘要翻译： 本发明涉及作为酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物。 具体地，公开了式I化合物或其药学上可接受的盐或溶剂合物，其中式I中的每个取代基在说明书中定义。 还公开了式I化合物的制备方法，药物组合物及其药物用途。 式I化合物是有效的酪氨酸激酶抑制剂。

公开(公告)号：US20120208833A1

公开(公告)日：2012-08-16

申请号：US13498547

申请日：2010-09-20

申请人： Jingyi Wang ,  Chuanwen Fan ,  Long Zhang ,  Zhongru Guo ,  Ying Li ,  Shaobo Yang ,  Shousheng Yan ,  Jianrong Zhu ,  Qingmin Yang ,  Minghui Zhang

发明人： Jingyi Wang ,  Chuanwen Fan ,  Long Zhang ,  Zhongru Guo ,  Ying Li ,  Shaobo Yang ,  Shousheng Yan ,  Jianrong Zhu ,  Qingmin Yang ,  Minghui Zhang

IPC分类号： A61K31/517 ,  A61P35/04 ,  A61P35/02 ,  C07D405/10 ,  A61P35/00

CPC分类号： C07D405/04

摘要： The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

摘要翻译： 本发明涉及作为酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物。 具体地，公开了式I化合物或其药学上可接受的盐或溶剂合物，其中式I中的每个取代基在说明书中定义。 还公开了式I化合物的制备方法，药物组合物及其药物用途。 式I化合物是有效的酪氨酸激酶抑制剂。

公开(公告)号：US20120301547A1

公开(公告)日：2012-11-29

申请号：US13512402

申请日：2010-11-22

申请人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

发明人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

IPC分类号： A61K9/24 ,  B05D5/00 ,  A61P25/18 ,  A61K9/28 ,  A61K31/519

CPC分类号： A61K9/0004 ,  A61K9/2086 ,  A61K9/2866 ,  A61K31/517

摘要： A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

摘要翻译： 披露了一种帕培酮双层渗透泵控释片及其制备方法。 双层渗透泵控制释放片剂包括刚性膜，推层，药物层，隔离层和美容涂层，其中刚性膜含有半透性聚合物，致孔剂和/或增塑剂，并且具有 一个或多个药物释放孔在一端，推层包括膨胀材料，渗透剂，粘合剂，着色剂和润滑剂，药物层含有药物活性成分，亲水性聚合物，渗透剂，着色剂 ，润滑剂和抗静电剂，隔离层位于刚性膜的内表面和推层之间，并含有亲水性聚合物。 帕潘立酮双层渗透泵控释片剂在早期阶段呈现出药物释放速率的增加，药物释放速率在后期保持不变。

公开(公告)号：US08920835B2

公开(公告)日：2014-12-30

申请号：US13512402

申请日：2010-11-22

申请人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

发明人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K31/519 ,  A61P25/18 ,  B05D5/00 ,  A61K9/00 ,  A61K9/20 ,  A61K31/517

CPC分类号： A61K9/0004 ,  A61K9/2086 ,  A61K9/2866 ,  A61K31/517

摘要： A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

摘要翻译： 披露了一种帕培酮双层渗透泵控释片及其制备方法。 双层渗透泵控制释放片剂包括刚性膜，推层，药物层，隔离层和美容涂层，其中刚性膜含有半透性聚合物，致孔剂和/或增塑剂，并且具有 一个或多个药物释放孔在一端，推层包括膨胀材料，渗透剂，粘合剂，着色剂和润滑剂，药物层含有药物活性成分，亲水性聚合物，渗透剂，着色剂 ，润滑剂和抗静电剂，隔离层位于刚性膜的内表面和推层之间，并含有亲水性聚合物。 帕潘立酮双层渗透泵控释片剂在早期阶段呈现出药物释放速率的增加，药物释放速率在后期保持不变。

公开(公告)号：US08539927B2

公开(公告)日：2013-09-24

申请号：US13434700

申请日：2012-03-29

申请人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

发明人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

IPC分类号： F02F3/00

CPC分类号： F16J1/16 ,  F16C7/023 ,  F16C9/04 ,  F16J1/08 ,  Y10T29/49249 ,  Y10T29/49266 ,  Y10T29/49288 ,  Y10T74/2142 ,  Y10T74/2162 ,  Y10T74/2173

摘要： A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

摘要翻译： 提供了一种手腕销及其构件之间的磨损降低的方法，活塞，连杆及其构造方法。 腕针具有在构造成用于容纳在活塞销孔中的相对端部之间延伸的第一部分和在构造成用于容纳在销孔中的相对端之间延伸的第二部分。 第二部分被配置为与第一部分相对移动。 活塞包括具有轴向对齐的销孔的活塞体，其中至少一个销孔具有防止腕销构件相对旋转的特征。 连杆包括具有小端孔的连杆主体。 小端孔具有允许第一腕针构件相对旋转的轮廓，并且具有防止第二腕针构件在其中的相对旋转的特征。

公开(公告)号：US08286607B2

公开(公告)日：2012-10-16

申请号：US12488853

申请日：2009-06-22

申请人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

发明人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

IPC分类号： F16J1/14

CPC分类号： F16J1/16 ,  F16C7/023 ,  F16C9/04 ,  F16J1/08 ,  Y10T29/49249 ,  Y10T29/49266 ,  Y10T29/49288 ,  Y10T74/2142 ,  Y10T74/2162 ,  Y10T74/2173

摘要： A piston assembly and method of assembly thereof, a wrist pin, a piston, a connecting rod, and methods of construction thereof is provided. The assembly includes a piston body having a pair laterally spaced pin bosses with a feature to prevent relative rotation of a first wrist pin member. The assembly has a connecting rod with a small end bore extending along a central axis and allowing relative rotation of the first wrist pin member and a feature with the small end bore to prevent relative rotation of a second wrist pin member. The first and second wrist pin members are moveable relative to one another, wherein the first and second members extend substantially parallel to the central axis through the small end bore.

摘要翻译： 提供一种活塞组件及其组装方法，一种腕针，活塞，连杆及其结构的方法。 组件包括具有一对侧向间隔开的销凸起的活塞体，具有防止第一腕销构件相对旋转的特征。 组件具有连接杆，其具有沿着中心轴线延伸的小端孔，并且允许第一腕针构件和具有小端孔的特征相对旋转以防止第二腕针构件相对旋转。 第一和第二腕销构件可相对于彼此移动，其中第一和第二构件基本平行于中心轴线延伸穿过小端孔。

公开(公告)号：US20090314244A1

公开(公告)日：2009-12-24

申请号：US12488853

申请日：2009-06-22

申请人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

发明人： Qingmin Yang ,  Andrew Miller ,  Frank Zlamal

IPC分类号： F02F3/00 ,  F02B75/32

CPC分类号： F16J1/16 ,  F16C7/023 ,  F16C9/04 ,  F16J1/08 ,  Y10T29/49249 ,  Y10T29/49266 ,  Y10T29/49288 ,  Y10T74/2142 ,  Y10T74/2162 ,  Y10T74/2173

摘要： A piston assembly and method of assembly thereof, a wrist pin, a piston, a connecting rod, and methods of construction thereof is provided. The assembly includes a piston body having a pair laterally spaced pin bosses with a feature to prevent relative rotation of a first wrist pin member. The assembly has a connecting rod with a small end bore extending along a central axis and allowing relative rotation of the first wrist pin member and a feature with the small end bore to prevent relative rotation of a second wrist pin member. The first and second wrist pin members are moveable relative to one another, wherein the first and second members extend substantially parallel to the central axis through the small end bore.

摘要翻译： 提供一种活塞组件及其组装方法，一种腕针，活塞，连杆及其结构的方法。 组件包括具有一对侧向间隔开的销凸起的活塞体，具有防止第一腕销构件相对旋转的特征。 组件具有连接杆，其具有沿着中心轴线延伸的小端孔，并且允许第一腕针构件和具有小端孔的特征相对旋转以防止第二腕针构件相对旋转。 第一和第二腕销构件可相对于彼此移动，其中第一和第二构件基本平行于中心轴线延伸穿过小端孔。

公开(公告)号：US06481895B2

公开(公告)日：2002-11-19

申请号：US09760875

申请日：2001-01-16

申请人： Qingmin Yang ,  Robert L. Stone

发明人： Qingmin Yang ,  Robert L. Stone

IPC分类号： F16C902

CPC分类号： F16C33/1075 ,  F16C9/02 ,  F16C17/04 ,  F16C17/047 ,  F16C17/10 ,  F16C43/02 ,  F16C2360/22

摘要： A crank shaft thrust bearing half includes a semi-cylindrical bearing shell carrying a pair of radially outwardly projecting thrust flanges having outer thrust surfaces. Radial grooves are formed in the thrust face to divide the surface into thrust pads. Each thrust pad has hydrodynamic contours which provide a hydrodynamic wedging action during rotation of the shaft to support high thrust loads. The thrust pad at the trailing end of the flange has an elevated land area spaced about 30° away from the trailing end and includes a long relief area from the land to the end to provide a no contact zone of the flange. Locating the land away from the trailing end and providing the relief zone shifts the peak pressure location away from the end and toward the middle of the bearing to relieve the trailing end from stress. Having radially oriented oil grooves with suitable width enables adequate oil supply and improved hydrodynamic oil film generating capability.