- 专利标题： Epigenetic co-repressors of the gamma-globin gene and methods of using same
-
申请号： US13480036申请日： 2012-05-24
-
公开(公告)号： US08916608B2公开(公告)日： 2014-12-23
- 发明人: James Douglas Engel , Osamu Tanabe , Lihong Shi
- 申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
- 申请人地址： US MI Ann Arbor
- 专利权人： Regents of the University of Michigan
- 当前专利权人： Regents of the University of Michigan
- 当前专利权人地址： US MI Ann Arbor
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61P7/00
- IPC分类号： A61P7/00 ; A61K31/708 ; G01N33/68 ; G01N33/80
摘要：
This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
公开/授权文献
信息查询
