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1.发明申请EPIGENETIC CO-REPRESSORS OF THE GAMMA-GLOBIN GENE AND METHODS OF USING SAME 有权GAMMA-GLOBIN基因的偶联共同重组体及其使用方法公开(公告)号：US20130059806A1
公开(公告)日：2013-03-07
申请号：US13480036
申请日：2012-05-24
申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
发明人： James Douglas Engel , Osamu Tanabe , Lihong Shi
IPC分类号： A61K31/704 , G01N21/76 , A61K31/706 , A61P7/00 , A61K31/708 , A61K31/27 , C12Q1/02 , A61K31/135
CPC分类号： G01N33/6854 , A61K31/135 , A61K31/145 , A61K31/7068 , A61K31/708 , G01N33/80 , G01N2333/91017 , G01N2500/10
摘要： This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
摘要翻译： 本公开描述了筛选化合物的方法，该化合物破坏DNMT1与γ-珠蛋白启动子之间或LSD-1与γ-珠蛋白启动子之间的相互作用。 本公开描述了筛选抑制γ-珠蛋白基因的化合物的方法。
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2.发明授权Epigenetic co-repressors of the gamma-globin gene and methods of using same 有权γ-珠蛋白基因的表观遗传学共抑制因子及其使用方法公开(公告)号：US08975293B2
公开(公告)日：2015-03-10
申请号：US13480036
申请日：2012-05-24
申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
发明人： James Douglas Engel , Osamu Tanabe , Lihong Shi
IPC分类号： A61P7/00 , A61K31/708 , G01N33/68 , G01N33/80
CPC分类号： G01N33/6854 , A61K31/135 , A61K31/145 , A61K31/7068 , A61K31/708 , G01N33/80 , G01N2333/91017 , G01N2500/10
摘要： This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
摘要翻译： 本公开描述了筛选化合物的方法，该化合物破坏DNMT1与γ-珠蛋白启动子之间或LSD-1与γ-珠蛋白启动子之间的相互作用。 本公开描述了筛选抑制γ-珠蛋白基因的化合物的方法。
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公开(公告)号：US08916608B2
公开(公告)日：2014-12-23
申请号：US13480036
申请日：2012-05-24
申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
发明人： James Douglas Engel , Osamu Tanabe , Lihong Shi
IPC分类号： A61P7/00 , A61K31/708 , G01N33/68 , G01N33/80
摘要： This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
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