Embodiments of a system and method for transmitting data from an access point in a multiple user multiple input multiple output (MU-MIMO) system are provided. A first indication of signal quality (ISQ) is received at the access point from a first station and a second ISQ is received from a second station. The access point sets a first power level and a first modulation and coding scheme (MCS) for transmission of a first aggregated media access control (MAC) protocol data unit (A-MPDU) to the first station as a function of the first ISQ and an amount of payload data corresponding to the first A-MPDU. The access point also sets a second power level and a second MCS for transmission of a second A-MPDU as a function of the second ISQ and an amount of payload data corresponding to the second A-MPDU.