Reactor vessels with pressure and heat transfer features for producing hydrogen-based fuels and structural elements, and associated systems and methods. A representative reactor system includes a first reaction zone and a heat path, a reactant source coupled to the first reaction zone, and a first actuator coupled to cyclically pressurize the first reaction zone. A second reaction zone is in fluid communication with the first, a valve is coupled between the first and second reaction zones to control a flow rate therebetween, and a second actuator is coupled in fluid communication with the second reaction zone to cyclically pressurize the second reaction zone. First and second heat exchangers direct heat from products to reactants in the reaction zones. A controller controls the first and second actuators in a coordinated manner based at least in part on a flow rate of the second product from the second reaction zone.