发明授权
US08927535B2 Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
有权
环丙基稠合-1,3-噻二嗪作为BACE1和/或BACE2抑制剂
- 专利标题： Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
- 专利标题（中）： 环丙基稠合-1,3-噻二嗪作为BACE1和/或BACE2抑制剂
-
申请号： US13537118申请日： 2012-06-29
-
公开(公告)号： US08927535B2公开(公告)日： 2015-01-06
- 发明人: Thomas Woltering
- 申请人： Thomas Woltering
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 优先权： EP11172784 20110706
- 主分类号： A61K31/554
- IPC分类号： A61K31/554 ; C07D417/12
摘要：
The present invention provides cyclopropyl-fused-1,3-thiazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
公开/授权文献
信息查询
