Invention Grant
US08927758B2 Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine
有权
（3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的拆分方法，适用于伊伐布雷定
![Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine](/docs/US/2015-01-06/US08927758B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine
- Patent Title (中): （3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的拆分方法，适用于伊伐布雷定
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Application No.: US13850501Application Date: 2013-03-26
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Publication No.: US08927758B2Publication Date: 2015-01-06
- Inventor: Jean-Michel Lerestif , Jean-Pierre Lecouve , Daniel Dron , Eric Gojon , Maryse Phan
- Applicant: Les Laboratoires Servier
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratories Servier
- Current Assignee: Les Laboratories Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: FR0804755 20080829
- Main IPC: C07C255/00
- IPC: C07C255/00 ; C07C211/00 ; C07C253/30 ; C07D223/16 ; C07C209/48 ; C07C255/47 ; C07D223/10
![Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine](/abs-image/US/2015/01/06/US08927758B2/abs.jpg.150x150.jpg)
Abstract:
Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
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