发明授权
US08932606B2 Chimeric pestivirus with insertion in 3′ nontranslated region (3′NTR) with stable replication and rnase resistance
有权
嵌合瘟病毒插入3'非翻译区（3'NTR），具有稳定的复制和抗性
- 专利标题： Chimeric pestivirus with insertion in 3′ nontranslated region (3′NTR) with stable replication and rnase resistance
- 专利标题（中）： 嵌合瘟病毒插入3'非翻译区（3'NTR），具有稳定的复制和抗性
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申请号： US13131027申请日： 2009-11-24
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公开(公告)号： US08932606B2公开(公告)日： 2015-01-13
- 发明人: Erhard Schoenbrunner , Sven-Erik Behrens
- 申请人： Erhard Schoenbrunner , Sven-Erik Behrens
- 申请人地址： US CA Carlsbad
- 专利权人： Life Technologies Corporation
- 当前专利权人： Life Technologies Corporation
- 当前专利权人地址： US CA Carlsbad
- 国际申请： PCT/US2009/065826 WO 20091124
- 国际公布： WO2010/060114 WO 20100527
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/15 ; A61K39/193 ; A61K39/29 ; C12N7/00
摘要：
The construction of a chimeric Pestivirus by the identification of selected regions in the 3′NTR of the viral RNA genome is described where additional RNA sequences can be stably inserted. These sequence insertions in the viral RNA genome were stable in replication and capable of forming infectious, RNase resistant virus particles. This chimeric Pestivirus with a 3′NTR insertion can be utilized as a quality control material in analytical assays for RNA targets, including external, internal controls, quantitative standards in PCR and NAT nucleic acid assays.
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