发明授权
- 专利标题： Method for selecting reduced differentiation resistance human induced pluripotent stem cells
- 专利标题（中）： 选择降低分化能力的人诱导多能干细胞的方法
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申请号： US13704584申请日： 2011-06-15
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公开(公告)号： US08932857B2公开(公告)日： 2015-01-13
- 发明人: Shinya Yamanaka , Kazutoshi Takahashi , Mari Ohnuki
- 申请人： Shinya Yamanaka , Kazutoshi Takahashi , Mari Ohnuki
- 申请人地址： JP Kyoto
- 专利权人： Kyoto University
- 当前专利权人： Kyoto University
- 当前专利权人地址： JP Kyoto
- 代理机构： Knobbe, Martens, Olson & Bear, LLP
- 国际申请： PCT/JP2011/064195 WO 20110615
- 国际公布： WO2011/158960 WO 20111222
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N5/074
摘要：
The present invention provides a method for selecting human induced pluripotent stem (iPS) cells which can be safely used for transplantation. That is, the present invention provides a method for selecting human iPS cells having reduced differentiation resistance, comprising the steps of: (1) inducing differentiation of human iPS cells; (2) detecting remaining undifferentiated cells after the step (1); and (3) selecting human iPS cells whose rate of remaining undifferentiated cells detected in step (2) is equivalent to or not more than that of control cells.
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