Invention Grant
US08936918B2 Yeast strain for the production of proteins with modified O-glycosylation
有权
用于生产具有修饰的O-糖基化的蛋白质的酵母菌株
- Patent Title: Yeast strain for the production of proteins with modified O-glycosylation
- Patent Title (中): 用于生产具有修饰的O-糖基化的蛋白质的酵母菌株
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Application No.: US13978714Application Date: 2012-02-20
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Publication No.: US08936918B2Publication Date: 2015-01-20
- Inventor: Piotr Bobrowicz , William J. Cook , Stephen Hamilton , Juergen Nett , Terrance A. Stadheim , Stefan Wildt
- Applicant: Piotr Bobrowicz , William J. Cook , Stephen Hamilton , Juergen Nett , Terrance A. Stadheim , Stefan Wildt
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US2012/025809 WO 20120220
- International Announcement: WO2012/115903 WO 20120830
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C07K14/39 ; C12P21/00 ; C12N9/90
Abstract:
Lower eukaryotic host cells have been recombinantly engineered to produce glycoprotein having human-like O-glycosylation. The glycoproteins are useful for the production of glycoprotein compositions with advantages for the production of human therapeutics.
Public/Granted literature
- US20130295608A1 YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATION Public/Granted day:2013-11-07
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