发明授权
US08936918B2 Yeast strain for the production of proteins with modified O-glycosylation
有权
用于生产具有修饰的O-糖基化的蛋白质的酵母菌株
- 专利标题: Yeast strain for the production of proteins with modified O-glycosylation
- 专利标题(中): 用于生产具有修饰的O-糖基化的蛋白质的酵母菌株
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申请号: US13978714申请日: 2012-02-20
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公开(公告)号: US08936918B2公开(公告)日: 2015-01-20
- 发明人: Piotr Bobrowicz , William J. Cook , Stephen Hamilton , Juergen Nett , Terrance A. Stadheim , Stefan Wildt
- 申请人: Piotr Bobrowicz , William J. Cook , Stephen Hamilton , Juergen Nett , Terrance A. Stadheim , Stefan Wildt
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 国际申请: PCT/US2012/025809 WO 20120220
- 国际公布: WO2012/115903 WO 20120830
- 主分类号: C12P21/06
- IPC分类号: C12P21/06 ; C07K14/39 ; C12P21/00 ; C12N9/90
摘要:
Lower eukaryotic host cells have been recombinantly engineered to produce glycoprotein having human-like O-glycosylation. The glycoproteins are useful for the production of glycoprotein compositions with advantages for the production of human therapeutics.
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