Invention Grant
US08940327B2 Agent for enhancing anti-tumor effect comprising oxaliplatin liposome preparation, and anti-tumor agent comprising the liposome preparation
有权
包含奥沙利铂脂质体制剂的增强抗肿瘤效果的药剂和包含脂质体制剂的抗肿瘤剂
- Patent Title: Agent for enhancing anti-tumor effect comprising oxaliplatin liposome preparation, and anti-tumor agent comprising the liposome preparation
- Patent Title (中): 包含奥沙利铂脂质体制剂的增强抗肿瘤效果的药剂和包含脂质体制剂的抗肿瘤剂
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Application No.: US12864280Application Date: 2009-01-29
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Publication No.: US08940327B2Publication Date: 2015-01-27
- Inventor: Tatsuhiro Ishida , Hiroshi Kiwada
- Applicant: Tatsuhiro Ishida , Hiroshi Kiwada
- Applicant Address: JP Tokushima-shi, Tokushima JP Tokyo
- Assignee: The University of Tokushima,Taiho Pharmaceutical Co. Ltd.
- Current Assignee: The University of Tokushima,Taiho Pharmaceutical Co. Ltd.
- Current Assignee Address: JP Tokushima-shi, Tokushima JP Tokyo
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Priority: JP2008-019141 20080130; JP2008-306072 20081201
- International Application: PCT/JP2009/051499 WO 20090129
- International Announcement: WO2009/096487 WO 20090806
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K31/282 ; A61K31/4412 ; A61K31/505 ; A61K31/513 ; A61K31/53 ; A61K31/555
Abstract:
An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil potassium. According to the present invention, by using oxaliplatin encapsulated in a liposome preparation, combination therapy of oxaliplatin plus a combination drug containing tegafur, gimeracil and oteracil potassium, is revealed to show remarkably enhanced antitumor effect without increasing side effects.
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