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1.发明申请POLYOXYALKYLENE CHAIN-CONTAINING LIPID DERIVATIVE AND LIPID FILM STRUCTURE CONTAINING SUCH DERIVATIVE 审中-公开含有这种衍生物的聚氧乙烯链脂质衍生物和脂质膜结构公开(公告)号：US20090202619A1
公开(公告)日：2009-08-13
申请号：US11816680
申请日：2006-02-17
Applicant: Hiroshi Kiwada , Tatsuhiro Ishida , Chika Ito , Kazuhiro Kubo , Kenji Sakanoue , Hiroshi Kikuchi
Inventor： Hiroshi Kiwada , Tatsuhiro Ishida , Chika Ito , Kazuhiro Kubo , Kenji Sakanoue , Hiroshi Kikuchi
CPC classification number: C07K7/06 , A61K9/1271 , A61K47/60 , A61K47/62 , C07K5/0806 , C07K5/1008
Abstract: A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.
Abstract translation: 由下式（1）表示的含有聚氧化烯链的脂质衍生物：其中L，Y，W，X1，X2，X3，OA，Z，m1，m2，m3，n1，n2和n3如上所定义 在规范中。
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2.发明授权Agent for enhancing anti-tumor effect comprising oxaliplatin liposome preparation, and anti-tumor agent comprising the liposome preparation 有权包含奥沙利铂脂质体制剂的增强抗肿瘤效果的药剂和包含脂质体制剂的抗肿瘤剂公开(公告)号：US08940327B2
公开(公告)日：2015-01-27
申请号：US12864280
申请日：2009-01-29
Applicant: Tatsuhiro Ishida , Hiroshi Kiwada
Inventor： Tatsuhiro Ishida , Hiroshi Kiwada
IPC: A61K9/127 , A61K31/282 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/555
CPC classification number: A61K31/282 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/555 , A61K2300/00
Abstract: An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil potassium. According to the present invention, by using oxaliplatin encapsulated in a liposome preparation, combination therapy of oxaliplatin plus a combination drug containing tegafur, gimeracil and oteracil potassium, is revealed to show remarkably enhanced antitumor effect without increasing side effects.
Abstract translation: 本发明的目的是进一步增强奥沙利铂与含有替加氟，吉莫斯特和奥特拉西钾的组合药联合施用时的抗肿瘤作用。 根据本发明，通过使用包封在脂质体制剂中的奥沙利铂，显示了奥沙利铂加上含有替加氟，吉莫斯特和奥特拉西钾的组合药物的组合疗法，显示出显着提高的抗肿瘤效果而不增加副作用。
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3.发明申请AGENT FOR ENHANCING ANTI-TUMOR EFFECT COMPRISING OXALIPLATIN LIPOSOME PREPARATION, AND ANTI-TUMOR AGENT COMPRISING THE LIPOSOME PREPARATION 有权用于增强包含OXALIPLATIN脂质体制剂的抗肿瘤效应的药剂和包含脂多糖制剂的抗肿瘤剂公开(公告)号：US20100330166A1
公开(公告)日：2010-12-30
申请号：US12864280
申请日：2009-01-29
Applicant: Tatsuhiro Ishida , Hiroshi Kiwada
Inventor： Tatsuhiro Ishida , Hiroshi Kiwada
CPC classification number: A61K31/282 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/555 , A61K2300/00
Abstract: An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil potassium. According to the present invention, by using oxaliplatin encapsulated in a liposome preparation, combination therapy of oxaliplatin plus a combination drug containing tegafur, gimeracil and oteracil potassium, is revealed to show remarkably enhanced antitumor effect without increasing side effects.
Abstract translation: 本发明的目的是进一步增强奥沙利铂与含有替加氟，吉莫斯特和奥特拉西钾的组合药联合施用时的抗肿瘤作用。 根据本发明，通过使用包封在脂质体制剂中的奥沙利铂，显示了奥沙利铂加上含有替加氟，吉莫斯特和奥特拉西钾的组合药物的组合疗法，显示出显着提高的抗肿瘤效果而不增加副作用。
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