发明授权
- 专利标题： Water-soluble CC-1065 analogs and their conjugates
- 专利标题（中）： 水溶性CC-1065类似物及其偶联物
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申请号： US12223682申请日： 2007-02-02
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公开(公告)号： US08940784B2公开(公告)日： 2015-01-27
- 发明人: Patrick Henry Beusker , Franciscus Marinus Hendrikus de Groot , Lutz F. Tietze , Felix Major , Johannes Albertus Frederikus Joosten , Henri Johannes Spijker
- 申请人： Patrick Henry Beusker , Franciscus Marinus Hendrikus de Groot , Lutz F. Tietze , Felix Major , Johannes Albertus Frederikus Joosten , Henri Johannes Spijker
- 申请人地址： NL Nijmegen
- 专利权人： Syntarga B.V.
- 当前专利权人： Syntarga B.V.
- 当前专利权人地址： NL Nijmegen
- 代理商 Mark R. Buscher
- 优先权： WOPCT/NL2006/050020 20060202
- 国际申请： PCT/NL2007/050043 WO 20070202
- 国际公布： WO2007/089149 WO 20070809
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/545 ; A61K31/404 ; C07D413/14 ; C07D401/14 ; C07D403/06 ; C07D209/60 ; A61K31/454 ; C07D403/14 ; C07H17/02
摘要：
This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
公开/授权文献
- US20090318668A1 Water-Soluble CC-1065 Analogs and Their Conjugates 公开/授权日：2009-12-24
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