公开(公告)号：US20120074150A1

公开(公告)日：2012-03-29

申请号：US13247452

申请日：2011-09-28

申请人： Jürgen Wortmann ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer ,  Karolin Geyer

发明人： Jürgen Wortmann ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer ,  Karolin Geyer

IPC分类号： A47J41/00

CPC分类号： F28D20/0034 ,  F24S60/00 ,  F28D2020/0047 ,  F28F2265/14 ,  F28F2270/00 ,  Y02E10/40 ,  Y02E60/142

摘要： The invention relates to a device for receiving hot, corrosively acting liquids (7), comprising a space enclosed by a wall (21) for receiving the liquid (7), the space having an inner insulation (19). The invention also relates to the use of the device for storing corrosively acting liquids for storing a heat storage medium comprising sulfur.

摘要翻译： 本发明涉及一种用于接收热的，具有腐蚀作用的液体（7）的装置，包括由用于接收液体（7）的壁（21）包围的空间，所述空间具有内绝缘体（19）。 本发明还涉及该装置用于储存用于储存包含硫的储热介质的腐蚀性作用液体的用途。

公开(公告)号：US20110271953A1

公开(公告)日：2011-11-10

申请号：US13100587

申请日：2011-05-04

申请人： Jürgen Wortmann ,  Claus Schäfer ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer

发明人： Jürgen Wortmann ,  Claus Schäfer ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer

IPC分类号： F24J2/34 ,  B65D6/12 ,  F24J2/30 ,  F28D17/00

CPC分类号： F28D20/0034 ,  F28D20/0039 ,  F28D2020/0047 ,  F28D2020/0069 ,  F28D2020/0091 ,  Y02E60/142

摘要： The invention relates to a device for storing heat, comprising a heat storage medium which absorbs heat in order to store heat and releases heat in order to use the stored heat, and a container for holding the heat storage medium, the container being closed by a gastight cover, and the device comprising volume compensation means in order to compensate for a volume increase of the heat storage medium (3) due to a temperature rise and a volume decrease due to a temperature reduction. The invention furthermore relates to a method for storing heat, in which heat is transferred to a heat storage medium in order to store heat or heat is discharged from the heat storage medium to the heat carrier in order to use the heat, the heat storage medium being held in a container which is closed by a gastight cover, wherein a volume expansion of the heat storage medium (3) is compensated for by a volume increase of the container (1) or by heat storage medium (3) flowing out of the container (1) into a buffer container (21; 63, 65), and a volume decrease of the heat storage medium (3) is compensated for by a volume decrease of the container (1) or by heat storage medium (3) flowing out of the buffer container (21; 63, 65) into the container (1).

摘要翻译： 本发明涉及一种用于储存热量的装置，其特征在于包括：为了储存热而吸收热量并释放热量的热存储介质，以及用于保存储热介质的容器，容器被一个 气密罩，以及包括体积补偿装置的装置，以便补偿由于温度升高引起的储热介质（3）的体积增加和由于温度降低引起的体积减小。 本发明还涉及一种用于存储热量的方法，其中将热量传递到储热介质以储存热量或热量从热储存介质排放到热载体以便使用热量，储热介质 被保持在由气密盖封闭的容器中，其中蓄热介质（3）的体积膨胀由容器（1）的体积增加或通过储存介质（3）流出的储热介质 容器（1）进入缓冲容器（21; 63,65）中，并且通过容器（1）的体积减少或流动的储热介质（3）补偿储热介质（3）的体积减少 从缓冲容器（21; 63,65）中取出到容器（1）中。

公开(公告)号：US20090318668A1

公开(公告)日：2009-12-24

申请号：US12223682

申请日：2007-02-02

申请人： Patrick Henry Beusker ,  Franciscus Marinus Hendrikus De Groot ,  Lutz F. Tietze ,  Felix Major ,  Johannes Albertus Frederikus Joosten ,  Henri Johannes Spijker

发明人： Patrick Henry Beusker ,  Franciscus Marinus Hendrikus De Groot ,  Lutz F. Tietze ,  Felix Major ,  Johannes Albertus Frederikus Joosten ,  Henri Johannes Spijker

IPC分类号： C07D403/06 ,  C07D413/14 ,  C07D401/14 ,  C07H17/02 ,  C07K4/00

CPC分类号： C07D209/60 ,  A61K31/404 ,  A61K31/454 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07H17/02

摘要： This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

摘要翻译： 本发明涉及DNA结合烷化剂CC-1065及其缀合物的新型类似物。 此外，本发明涉及制备所述试剂及其共轭物的中间体。 缀合物被设计为在一个或多个活化步骤之后和/或在缀合物控制的速率和时间范围内释放它们的（多个）有效载荷，以选择性递送和/或可控地释放一种或多种所述DNA烷基化剂。 药剂，缀合物和中间体可用于治疗以不期望（细胞）增殖为特征的疾病。 作为实例，本发明的药剂和缀合物可用于治疗肿瘤。

公开(公告)号：US10168105B2

公开(公告)日：2019-01-01

申请号：US13100587

申请日：2011-05-04

申请人： Jürgen Wortmann ,  Claus Schäfer ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer

发明人： Jürgen Wortmann ,  Claus Schäfer ,  Michael Lutz ,  Fabian Seeler ,  Martin Gärtner ,  Felix Major ,  Kerstin Schierle-Arndt ,  Otto Machhammer ,  Günther Huber ,  Stephan Maurer

IPC分类号： F24J2/34 ,  F28D20/00

摘要： The invention relates to a device for storing heat, comprising a heat storage medium which absorbs heat in order to store heat and releases heat in order to use the stored heat, and a container for holding the heat storage medium, the container being closed by a gastight cover, and the device comprising volume compensation means in order to compensate for a volume increase of the heat storage medium (3) due to a temperature rise and a volume decrease due to a temperature reduction. The invention furthermore relates to a method for storing heat, in which heat is transferred to a heat storage medium in order to store heat or heat is discharged from the heat storage medium to the heat carrier in order to use the heat, the heat storage medium being held in a container which is closed by a gastight cover, wherein a volume expansion of the heat storage medium (3) is compensated for by a volume increase of the container (1) or by heat storage medium (3) flowing out of the container (1) into a buffer container (21; 63, 65), and a volume decrease of the heat storage medium (3) is compensated for by a volume decrease of the container (1) or by heat storage medium (3) flowing out of the buffer container (21; 63, 65) into the container (1).

公开(公告)号：US08940784B2

公开(公告)日：2015-01-27

申请号：US12223682

申请日：2007-02-02

申请人： Patrick Henry Beusker ,  Franciscus Marinus Hendrikus de Groot ,  Lutz F. Tietze ,  Felix Major ,  Johannes Albertus Frederikus Joosten ,  Henri Johannes Spijker

发明人： Patrick Henry Beusker ,  Franciscus Marinus Hendrikus de Groot ,  Lutz F. Tietze ,  Felix Major ,  Johannes Albertus Frederikus Joosten ,  Henri Johannes Spijker

IPC分类号： A61K31/5377 ,  A61K31/545 ,  A61K31/404 ,  C07D413/14 ,  C07D401/14 ,  C07D403/06 ,  C07D209/60 ,  A61K31/454 ,  C07D403/14 ,  C07H17/02

CPC分类号： C07D209/60 ,  A61K31/404 ,  A61K31/454 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07H17/02

摘要： This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

摘要翻译： 本发明涉及DNA结合烷化剂CC-1065及其缀合物的新型类似物。 此外，本发明涉及制备所述试剂及其共轭物的中间体。 缀合物被设计为在一个或多个活化步骤之后和/或在缀合物控制的速率和时间范围内释放它们的（多个）有效载荷，以选择性递送和/或可控地释放一种或多种所述DNA烷基化剂。 药剂，缀合物和中间体可用于治疗以不期望（细胞）增殖为特征的疾病。 作为实例，本发明的药剂和缀合物可用于治疗肿瘤。

公开(公告)号：US20110247606A1

公开(公告)日：2011-10-13

申请号：US13082585

申请日：2011-04-08

申请人： Felix Major ,  Fabian Seeler ,  Florian Garlichs ,  Martin Gärtner ,  Stephan Maurer ,  Jürgen Wortmann ,  Michael Lutz ,  Günther Huber ,  Otto Machhammer ,  Kerstin Schierle-Arndt

发明人： Felix Major ,  Fabian Seeler ,  Florian Garlichs ,  Martin Gärtner ,  Stephan Maurer ,  Jürgen Wortmann ,  Michael Lutz ,  Günther Huber ,  Otto Machhammer ,  Kerstin Schierle-Arndt

IPC分类号： F24J2/48 ,  F24J2/04 ,  C09K5/00

CPC分类号： C09K5/12 ,  F24S80/20 ,  F28D20/00 ,  Y02E10/40 ,  Y02E60/142

摘要： Mixture comprising elemental sulfur and an additive comprising anions.

摘要翻译： 包含元素硫和包含阴离子的添加​​剂的混合物。

公开(公告)号：US20120217681A1

公开(公告)日：2012-08-30

申请号：US13508268

申请日：2010-10-26

申请人： Roman Zieba ,  Felix Major ,  Evgueni Klimov ,  Alexander Traut ,  Laurence Pottie ,  Bernd Smarsly ,  Rainer Ostermann

发明人： Roman Zieba ,  Felix Major ,  Evgueni Klimov ,  Alexander Traut ,  Laurence Pottie ,  Bernd Smarsly ,  Rainer Ostermann

IPC分类号： B29C47/00

CPC分类号： D01F9/08 ,  B82Y30/00 ,  C01G30/00 ,  C01P2004/16 ,  C01P2006/22 ,  C04B35/457 ,  C04B35/62231 ,  C04B35/62236 ,  C04B35/6225 ,  C04B35/62254 ,  C04B35/62259 ,  C04B35/6263 ,  C04B35/6264 ,  C04B35/632 ,  C04B35/63416 ,  C04B35/63424 ,  C04B35/63444 ,  C04B35/63456 ,  C04B35/63488 ,  C04B35/636 ,  C04B2235/3286 ,  C04B2235/3293 ,  C04B2235/3294 ,  C04B2235/441 ,  C04B2235/444 ,  C04B2235/5264 ,  C04B2235/5296 ,  C04B2235/9661 ,  D01D1/02 ,  D01D5/0038

摘要： The present invention relates to a process for producing metal oxide nanofibers using a sol-gel precursor. The nanofibers produced by the process according to the invention are notable for an increased metal oxide content compared to the prior art.

摘要翻译： 本发明涉及使用溶胶 - 凝胶前体制备金属氧化物纳米纤维的方法。 通过根据本发明的方法生产的纳米纤维与现有技术相比，值得注意的是增加的金属氧化物含量。

公开(公告)号：US20110163258A1

公开(公告)日：2011-07-07

申请号：US12979431

申请日：2010-12-28

申请人： Fabian Seeler ,  Felix Major ,  Kerstin Schierle-Arndt ,  Jürgen Wortmann ,  Martin Gärtner ,  Michael Lutz ,  Stephan Maurer ,  Otto Machhammer ,  Günther Huber ,  Hans-Josef Sterzel

发明人： Fabian Seeler ,  Felix Major ,  Kerstin Schierle-Arndt ,  Jürgen Wortmann ,  Martin Gärtner ,  Michael Lutz ,  Stephan Maurer ,  Otto Machhammer ,  Günther Huber ,  Hans-Josef Sterzel

IPC分类号： C09K5/00

CPC分类号： C09K5/12 ,  C01B17/34 ,  Y02P20/13 ,  Y02P20/134

摘要： The present invention relates to mixtures of alkali metal polysulfides and to mixtures of alkali metal polysulfides and alkali metal thiocyanates, to processes for preparation thereof, to the use thereof as heat transfer or heat storage fluids, and to heat transfer or heat storage fluids which comprise the mixtures of alkali metal polysulfides or the mixtures of alkali metal polysulfides and alkali metal thiocyanates.

摘要翻译： 本发明涉及碱金属多硫化物的混合物和碱金属多硫化物和碱金属硫氰酸盐的混合物，其制备方法，其作为热传递或蓄热流体的用途，以及包含 碱金属多硫化物的混合物或碱金属多硫化物和碱金属硫氰酸盐的混合物。