An apparatus and a method for a cluster-based power control at a macro base station in a wireless communication system are provided. The method includes broadcasting an interference allowance value determined based on a predefined aggregate interference to a femto cell, updating the interference allowance value with consideration of a channel activity for each femto cell group on a cluster basis, and when detecting a change in an aggregate interference generated due to femto cell power allocation, repeating determination of an interference allowance value so that a Quality of Service (QoS) of a macro cell user is met, and broadcasting the interference allowance value to a femto cell.