Delivery systems and methods of creating an accessory maxillary ostium and implanting a ventilation tube for purposes of ventilation, irrigation, infusion or procedural work are described. The delivery systems include an introducer and an associated ventilation tube. An irrigation and/or infusion catheter may be advanced through the ventilation tube in order to irrigate or express the contents of the sinus cavities. A secondary irrigation and/or infusion catheter or a balloon catheter may be advanced through an outer irrigation and/or infusion catheter, deeply into the sinus cavity, in order to irrigate or express the contents of the sinus cavities. Moreover, the balloon catheter may alternatively or additionally be employed to for dilation of the natural ostium. Still further, a device for delivering drugs, fluids or the like, may be coupled to the ventilation tube for delivery of same.