In described embodiments, data pattern-based detection of loss of signal (LOS) is employed for a receive path of serializer/deserializer (SerDes) devices. Pattern-based LOS detection allows for detection of data loss over variety of types of connection media, and is generally insensitive to signal attenuation. More specifically, some described embodiments disclose reliable pattern-based detection of LOS across different connection media for incoming receive data when discreet time decision feedback equalization (DFE) is employed.