发明授权
US08956607B2 Humanized anti-IL 10 antibodies for the treatment of systemic lupus erythematosus (SLE)
有权
用于治疗系统性红斑狼疮（SLE）的人源化抗IL 10抗体
- 专利标题： Humanized anti-IL 10 antibodies for the treatment of systemic lupus erythematosus (SLE)
- 专利标题（中）： 用于治疗系统性红斑狼疮（SLE）的人源化抗IL 10抗体
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申请号： US13512712申请日： 2010-11-30
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公开(公告)号： US08956607B2公开(公告)日： 2015-02-17
- 发明人: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
- 申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
- 申请人地址： DE Dreieich
- 专利权人： Biotest AG
- 当前专利权人： Biotest AG
- 当前专利权人地址： DE Dreieich
- 代理机构： LeClair Ryan, a professional corporation
- 代理商 Robin L. Teskin
- 优先权： GB0920933.9 20091130; GB0920940.4 20091130; GB0920942.0 20091130
- 国际申请： PCT/EP2010/068569 WO 20101130
- 国际公布： WO2011/064399 WO 20110603
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C12N5/07 ; C12P21/08 ; C07K16/00 ; C07K16/24
摘要：
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.