发明授权
- 专利标题： Compositions and methods for treatment of cervical dysplasia
- 专利标题（中）： 用于治疗子宫颈发育不良的组合物和方法
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申请号： US13314583申请日： 2011-12-08
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公开(公告)号： US08956621B2公开(公告)日： 2015-02-17
- 发明人: Yvonne Paterson , John Rothman
- 申请人： Yvonne Paterson , John Rothman
- 申请人地址： US PA Philadelphia US NJ Princeton
- 专利权人： The Trustees of the University of Pennsylvania,Advaxis, Inc.
- 当前专利权人： The Trustees of the University of Pennsylvania,Advaxis, Inc.
- 当前专利权人地址： US PA Philadelphia US NJ Princeton
- 代理机构： Zedek Latzer Baratz LLP
- 代理商 Mark S. Cohen; Pearl Cohen
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61P35/00 ; A61K39/00 ; C07K14/195 ; C07K14/705
摘要：
The present invention provides methods of treating, protecting against, and inducing an immune response against cervical dysplasia and cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and an E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
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