发明授权
US08957188B2 Antibodies that bind GalNAc1-3Gal, pharmaceutical compositions and methods of using same
有权
结合GalNAc1-3Gal的抗体，药物组合物及其使用方法
- 专利标题： Antibodies that bind GalNAc1-3Gal, pharmaceutical compositions and methods of using same
- 专利标题（中）： 结合GalNAc1-3Gal的抗体，药物组合物及其使用方法
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申请号： US12752331申请日： 2010-04-01
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公开(公告)号： US08957188B2公开(公告)日： 2015-02-17
- 发明人: Jeffrey Gildersleeve , Zhitao Li , Qian Li , Miriam Anver , Donna O. Butcher
- 申请人： Jeffrey Gildersleeve , Zhitao Li , Qian Li , Miriam Anver , Donna O. Butcher
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/30 ; A61K51/10 ; G01N33/534
摘要：
Monoclonal antibodies to carbohydrate antigens containing a terminal GalNAcα1-3Gal are provided. The antibodies of the present invention are found to specifically recognize GalNAcα1-3Gal with little cross-reactivity to other structurally similar antigens such as GalNAcα1-6Gal, blood group A, Forssman antigen and the Tn antigen on both solution assays and human tissue. Compositions comprising the monoclonal antibodies, as well as methods of diagnosis, treatment and prognostication are also provided.
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