发明授权
US08961978B2 Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses
有权
能够中和系统发育组1和系统发育组2和乙型流感病毒的甲型流感病毒的人结合分子
- 专利标题： Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses
- 专利标题（中）： 能够中和系统发育组1和系统发育组2和乙型流感病毒的甲型流感病毒的人结合分子
-
申请号： US14126404申请日： 2012-07-12
-
公开(公告)号： US08961978B2公开(公告)日： 2015-02-24
- 发明人: Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
- 申请人： Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
- 申请人地址： NL Leiden
- 专利权人： Crucell Holland B.V.
- 当前专利权人： Crucell Holland B.V.
- 当前专利权人地址： NL Leiden
- 代理机构： TraskBritt
- 优先权： EP11173953 20110714
- 国际申请： PCT/EP2012/063637 WO 20120712
- 国际公布： WO2013/007770 WO 20130117
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; C12Q1/70 ; G01N33/53 ; C07K16/10 ; A61K39/42 ; A61K39/00
摘要：
The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.
公开/授权文献
信息查询
