发明授权
US08962618B2 Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
有权
二酰基甘油O-酰基转移酶1（DGAT-1）的抑制剂及其用途
- 专利标题： Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
- 专利标题（中）： 二酰基甘油O-酰基转移酶1（DGAT-1）的抑制剂及其用途
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申请号： US13458452申请日： 2012-04-27
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公开(公告)号： US08962618B2公开(公告)日： 2015-02-24
- 发明人: K. Raja Reddy , Jeff Stebbins , Serge H. Boyer , Mark D. Erion , Scott J. Hecker , Nicholas Brian Raffaele , Brett C. Bookser , Venkat Reddy Mali
- 申请人： K. Raja Reddy , Jeff Stebbins , Serge H. Boyer , Mark D. Erion , Scott J. Hecker , Nicholas Brian Raffaele , Brett C. Bookser , Venkat Reddy Mali
- 申请人地址： US CA La Jolla
- 专利权人： Metabasis Therapeutics, Inc.
- 当前专利权人： Metabasis Therapeutics, Inc.
- 当前专利权人地址： US CA La Jolla
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61K31/535 ; C07D513/00 ; C07D265/36 ; C07D498/02 ; C07F9/6561 ; A61K31/52 ; A61K31/662 ; A61K31/665 ; A61K31/675 ; A61K45/06 ; C07D473/16 ; C07D473/34 ; C07D473/40 ; C07F9/30 ; C07F9/32 ; C07F9/653 ; C07F9/6574
摘要：
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohdroxy pridines or primidines as diacylglycerol O-acyltransferase 1 DGAT-1 inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.
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