Invention Grant
US08969038B2 Bacterial host strain expressing recombinant DsbC and having reduced Tsp activity
有权
表达重组DsbC并具有降低的Tsp活性的细菌宿主菌株
- Patent Title: Bacterial host strain expressing recombinant DsbC and having reduced Tsp activity
- Patent Title (中): 表达重组DsbC并具有降低的Tsp活性的细菌宿主菌株
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Application No.: US13522083Application Date: 2011-01-13
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Publication No.: US08969038B2Publication Date: 2015-03-03
- Inventor: Mark Ellis , David Paul Humphreys
- Applicant: Mark Ellis , David Paul Humphreys
- Applicant Address: BE Brussels
- Assignee: UCB Pharma S.A.
- Current Assignee: UCB Pharma S.A.
- Current Assignee Address: BE Brussels
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB1000591.6 20100114
- International Application: PCT/EP2011/050416 WO 20110113
- International Announcement: WO2011/086139 WO 20110721
- Main IPC: C12N15/70
- IPC: C12N15/70 ; C12N15/09 ; C07K14/245
Abstract:
The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell.
Public/Granted literature
- US20120288894A1 BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC AND HAVING REDUCED TSP ACTIVITY Public/Granted day:2012-11-15
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