发明授权
US08969039B2 Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity
有权
包含突变体SPR基因并具有降低的TSP活性的细菌宿主菌株
- 专利标题： Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity
- 专利标题（中）： 包含突变体SPR基因并具有降低的TSP活性的细菌宿主菌株
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申请号： US13522087申请日： 2011-01-13
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公开(公告)号： US08969039B2公开(公告)日： 2015-03-03
- 发明人: Mark Ellis , David Paul Humphreys
- 申请人： Mark Ellis , David Paul Humphreys
- 申请人地址： BE Brussels
- 专利权人： UCB Pharma S.A.
- 当前专利权人： UCB Pharma S.A.
- 当前专利权人地址： BE Brussels
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 优先权： GB1000587.4 20100114
- 国际申请： PCT/EP2011/050413 WO 20110113
- 国际公布： WO2011/086136 WO 20110721
- 主分类号： C12N15/70
- IPC分类号： C12N15/70 ; C12N15/09 ; C07K14/245 ; C12N9/52
摘要：
The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.
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