Invention Grant
US08969039B2 Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity
有权
包含突变体SPR基因并具有降低的TSP活性的细菌宿主菌株
- Patent Title: Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity
- Patent Title (中): 包含突变体SPR基因并具有降低的TSP活性的细菌宿主菌株
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Application No.: US13522087Application Date: 2011-01-13
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Publication No.: US08969039B2Publication Date: 2015-03-03
- Inventor: Mark Ellis , David Paul Humphreys
- Applicant: Mark Ellis , David Paul Humphreys
- Applicant Address: BE Brussels
- Assignee: UCB Pharma S.A.
- Current Assignee: UCB Pharma S.A.
- Current Assignee Address: BE Brussels
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB1000587.4 20100114
- International Application: PCT/EP2011/050413 WO 20110113
- International Announcement: WO2011/086136 WO 20110721
- Main IPC: C12N15/70
- IPC: C12N15/70 ; C12N15/09 ; C07K14/245 ; C12N9/52
Abstract:
The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.
Public/Granted literature
- US20120295309A1 BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY Public/Granted day:2012-11-22
Information query
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