A method, computer program product, and system generating epigenetic cohorts for a specific time period through clustering of epigenetic surprisal data at a specific time comprising. receiving a phenotypic and/or demographic parameter and a cluster characteristics input from a user; searching the epigenetic surprisal data at a specific time for the parameter and storing matches in a repository; generating a cluster comprising a centroid for each parameter by populating the cluster based on the matches of the parameter with the epigenetic surprisal data at a specific time period; determining at least two epigenetic cohorts for a specific time period from the cluster for each parameter and based on the input from the user; and if the cohorts do not match the input of the user, reporting the cohorts determined to the user and returning to the step of receiving a parameter and characteristic input from a user.