发明授权
- 专利标题： Anti-alpha2 integrin antibodies and their uses
- 专利标题（中）： 抗α2整合素抗体及其用途
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申请号： US13578921申请日： 2011-02-22
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公开(公告)号： US08975376B2公开(公告)日： 2015-03-10
- 发明人: Stanislas Blein , Samuel Hou , Darko Skegro
- 申请人： Stanislas Blein , Samuel Hou , Darko Skegro
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 代理机构： Lathrop & Gage LLP
- 代理商 James H. Velema, Esq.
- 国际申请： PCT/IB2011/000344 WO 20110222
- 国际公布： WO2011/104604 WO 20110901
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/46 ; C07K16/28
摘要：
The invention relates to antibodies directed to α2β1 integrin and their uses, including humanized anti-alpha 2 (α2) integrin antibodies and methods of treatment with anti-α2integrin antibodies. More specifically the present invention relates to humanized anti-α2 integrin antibodies comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG1 heavy chain constant region which exhibit altered effector function.
公开/授权文献
- US20130052191A1 ANTI-ALPHA2 INTEGRIN ANTIBODIES AND THEIR USES 公开/授权日：2013-02-28
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