Invention Grant
- Patent Title: Tubulysin compounds, methods of making and use
- Patent Title (中): Tubulysin化合物，制造和使用方法
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Application No.: US14177376Application Date: 2014-02-11
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Publication No.: US08980824B2Publication Date: 2015-03-17
- Inventor: Qiang Cong , Heng Cheng , Sanjeev Gangwar
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/00 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K5/117 ; A61K47/48 ; C07K7/06 ; C07K5/06 ; C07K5/078
Abstract:
Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Public/Granted literature
- US20140227295A1 TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE Public/Granted day:2014-08-14
Information query
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